United States Air Force Academy

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Major Michael D. Barnhart

Assistant Professor of Biology

Department of Biology

SP
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Bio

Major Michael D. Barnhart is an Assistant Professor of Biology at the U.S. Air Force Academy, Colorado Springs, Colo. Major Barnhart serves as the Course Director for Microbiology and the Cadet Summer Research Program (CSRP) Lead. In this role, he directs the design and delivery of core microbiology instruction for future Air Force officers, oversees departmental compliance and biosafety programs, and leads the Academy’s premier undergraduate research initiative connecting cadets with Department of Defense laboratories, national research institutions, and industry partners.

Major Barnhart began his Air Force career as an enlisted Integrated Avionics Technician on the C-17 Globemaster III. Following his selection to the U.S. Air Force Academy, he commissioned as an Academy Scholar in 2011. After two deployments to Afghanistan as an operations group executive officer, he was competitively selected to return to the Academy as an instructor in the Department of Biology. His outstanding teaching and research performance led to his selection for doctoral study through the Air Force Institute of Technology’s Civilian Institution Program.

In 2022, Major Barnhart earned his Doctor of Philosophy in Biochemistry from the University of Cambridge, United Kingdom. Before returning to the Academy, he served as the Deputy Director of the Autonomy Capability Team (ACT3) within the Air Force Research Laboratory (AFRL), Wright-Patterson AFB, Ohio, where he led multidisciplinary teams developing and integrating Artificial Intelligence technologies across Department of the Air Force missions.

His research portfolio includes nine peer-reviewed publications spanning molecular biology, biochemistry, and chemical and biological defense. His recent paper, Phosphorylation of the Smooth Muscle Master Splicing Regulator, RBPMS-A, Regulates Its Splicing Activity, was nominated for a Breakthrough Designation by Nucleic Acids Research. Major Barnhart’s current academic interests center on microbiology education, biosafety and compliance leadership, and the integration of biotechnology and artificial intelligence in defense research and training.

Education

Air Command and Staff College (correspondence) (2024)

Doctor of Philosophy in Biochemistry, University of Cambridge, Cambridge, United Kingdom (2022)

Squadron Officer School, Maxwell Air Force Base, Ala. (2018)

Graduate Certificate in Nuclear Weapons, Effects, Policy and Proliferation, Air Force Institute of Technology, Dayton, Ohio (2015)

Master of Science in Cellular and Molecular Biology, Colorado State University, Fort Collins, Colo. (2013)

Bachelor of Science in Biology, Minor in French, United States Air Force Academy, Colorado Spring, Colo. (2011)

Avionic Systems Technology, Community College of the Air Force, Montgomery, Ala. (2005)

Professional Experience

Deputy Director ACT-3, Wright-Patterson AFB, Ohio (2024-2025)

Acting Director ACT-3, Wright-Patterson AFB, Ohio (2023)

Deputy Director ACT-3, Wright-Patterson AFB, Ohio (2022-2023)

PhD Graduate Student, University of Cambridge, Cambridge, United Kingdom (2019-2022)

Senior Instructor of Biology, United States Air Force Academy, Colorado Springs, Colo. (2018-2019)

Instructor of Biology, United States Air Force Academy, Colorado Springs, Colo. (2017-2018)

Executive Officer, 455 Expeditionary Operations Group, Bagram AFB, Afghanistan (2016-2017)

Counter-Proliferation Program Manager, Wright-Patterson AFB, Ohio (2013-2016)

Graduate Student, Colorado State University, Fort Collins, Colo. (2011-2013)

Student, United States Air Force Academy, Colorado Springs, Colo. (2007-2011)

Student, United States Air Force Academy Preparatory School, Colorado Springs, Colo. (2006-2007)

Integrated Avionics Systems Technician, 315th Maintenance Squadron, Charleston AFB, S.C. (2005-2006)

Honors & Awards

Meritorious Service Medal with Two Oak Leaf Clusters

Air and Space Commendation Medal with One Oak Leaf Cluster

National Defense Service Medal

Afghanistan Campaign Medal with one Service Star

Global War on Terrorism Expeditionary Medal

Global War on Terrorism Service Medal

NATO Medal

MAJCOM Air Force Medical Service Award – USAFA iGEM Team

USAF Biomedical Science Corp Team – U.S. Air Force Academy iGEM Team

711th Human Performance Wing Commander’s Excellence Award for Biosafety Team

U.S. Air Force Academy Scholar Graduate

Basic Military Training Honor Graduate

Research and Scholarly Interests

RNA splicing regulation

Post-transcriptional gene control

RNA binding proteins

mRNA stability and decay pathways

Virus-host interactions in RNA regulation

Stress-responsive RNA dynamics

Synthetic biology tools for sensing and detection

Engineering biological systems for applied research

RNA-centered mechanisms in cellular adaptation

Molecular responses to environmental or pathogenic stress

Publications

Phosphorylation of The Smooth Muscle Master Splicing Regulator, RBPMS-A, Regulates its Splicing Activity, Nucleic Acid Research, 2022

A Synthetic Biology Approach Using Engineered Bacteria to Detect Perfluoroalkyl Substance (PFAS) Contamination in Water, Military Medicine, 2021

Investing in Our Nation’s Future Military Leaders’ Synthetic Biology Knowledge to Understand and Recognize Threats and Applications, Synthetic Biology, 2019

The Effects of Threat Biological Warfare Agents on US Air Force Materials, Defense Technical Information Center, 2014

Analysis of CB Threat Challenges to Aircraft Employing Long Range Mission Profiles, Defense Technical Information Center, 2013

Changes in Cellular mRNA Stability, Splicing, and Polyadenylation through HuR Protein Sequestration by a Cytoplasmic RNA Virus, Cell Reports, 2013

Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasm, Journal of Biological Chemistry, 2012

Inhibition and avoidance of mRNA degradation by RNA viruses, Current Opinion in Microbiology, 2012

VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress, Proceedings of SPIE, 2011