United States Air Force Academy

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Dr. Seth Norrholm

Distinguished Visiting Professor

Department of Behavioral Sciences and Leadership

Dr. Norrholm
Contact Information

(719) 333-2514

Email

Bio

Seth D. Norrholm, PhD, is a translational neuroscientist with over 2 decades of research experience in furthering the understanding of the neurobiological mechanisms underlying fear-, anxiety-, trauma-, and stressor-related disorders and the psychiatric conditions with which these disorders are co-morbid. Dr. Norrholm has trained in both the “classical” bench-based neurosciences as well as within clinical arenas dedicated to the treatment of mood and anxiety disorders. Together with a network of collaborators, Dr. Norrholm has employed objective, psychophysiological methods to study the underpinnings of mammalian fear processing as well as the mechanisms mediating effective treatments for fear and anxiety. Dr. Norrholm has spent 20 years working within VA and DoD to develop effective treatment strategies for mood and anxiety disorders with interventions spanning pharmaceutical, surgical, behavioral, and alternative domains. He is a recognized world leader in posttraumatic stress disorder (PTSD) and Fear and recently joined our faculty as a Distinguished Visiting Professor in 2022.

When not working, Dr. Norrholm enjoys spending time with his wife and kids and their menagerie of animals as well as cheering on his beloved Florida State Seminoles and Philadelphia Eagles.

Education

B.A. in Psychology (1995) – University of Maryland at College Park, College Park, Maryland

M.A. in Neuroscience (1998) – University of Hartford/University of Connecticut Health Center, Hartford/Farmington, Connecticut

Ph.D. in Neuroscience (2001) – Florida State University, Tallahassee, Florida

Postdoctoral Fellow (2001-2003), College of Pharmacy, University of Kentucky

Postdoctoral Fellow (2003-2004), Department of Anatomy, University of South Florida

Postdoctoral Fellow (2004-2007), Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine

Ph.D. Respecialization in Clinical Psychology (2014-2019) – Emory University, Atlanta, Georgia

Professional Experience

2007 – 2008: Associate in Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

2008 – 2018: Assistant Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

2018 – 2019: Associate Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia

2014 – 2019: Full-time Faculty Member, Graduate Program in Neuroscience, Emory University, Atlanta, Georgia

2009 – 2019: Program Analyst/Principal Investigator, Atlanta VA Health Care System, Decatur, Georgia.

2019 – present: Associate Professor, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan

2019 – present: Scientific Director, Neuroscience Center for Anxiety, Stress, and Trauma (NeuroCAST), Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan

Honors & Awards

Recognized World Expert, Posttraumatic Stress Disorder, Expertscape, (2019)

Recognized World Expert, Fear, Expertscape, (2019)

Distinction in Scholarship Certificate, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology (2018)

Emory School of Medicine Researcher Appreciation Day Recognition (2018)

Military Medicine Article of the Year Award (2017)

National Institutes of Health, National Advisory Mental Health Council Workgroup on Tasks and Measures for Research Domain Criteria (RDoC), Recommended Paradigm, Acute Fear Construct, https://www.nimh.nih.gov/about/advisory-boards-and-groups/namhc/reports/behavioral-assessment-methods-for-rdoc-constructs#section-ii-a (2016)

Distinguished Scientific Contribution, Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences (2015)

Research and Scholarly Interests

Assessing the acquisition and extinction of learned fear using psychophysiological techniques (e.g., fear-potentiated startle, skin conductance, heart rate variability, and eye-tracking)

Clinical Psychopharmacology

Integrating objective measures of fear and anxiety during the implementation of cognitive behavioral therapies for mood and anxiety disorders

Virtual reality solutions for assessing the degree of and pathophysiological expression of fear

Imaginal and VR-based Prolonged Exposure Therapy

Learning and Memory

Publications

Acquisition, extinction, and return of fear in veterans in intensive outpatient prolonged exposure therapy: A fear-potentiated startle study.

Maples-Keller J, Watkins LE, Nylocks KM, Yasinski C, Coghlan C, Black K, Jovanovic T, Rauch SAM, Rothbaum BO, Norrholm SD.Behav Res Ther. 2022 Jul;154:104124. doi: 10.1016/j.brat.2022.104124. Epub 2022 May 20.PMID: 35642990

Does COVID-19 count?: Defining Criterion A trauma for diagnosing PTSD during a global crisis.

Norrholm SD, Zalta A, Zoellner L, Powers A, Tull MT, Reist C, Schnurr PP, Weathers F, Friedman MJ.Depress Anxiety. 2021 Sep;38(9):882-885. doi: 10.1002/da.23209.PMID: 34469042

An analysis of fear inhibition and fear extinction in a sample of veterans with obstructive sleep apnea (OSA): Implications for co-morbidity with post-traumatic stress disorder (PTSD).

Reist C, Jovanovic T, Kantarovich D, Weingast L, Hollifield M, Novin M, Khalaghizadeh S, Jafari B, George R, Riser M, Woodford J, Norrholm SD.Behav Brain Res. 2021 Apr 23;404:113172. doi: 10.1016/j.bbr.2021.113172. Epub 2021 Feb 9.PMID: 33577879

Changes in trauma-potentiated startle, skin conductance, and heart rate within prolonged exposure therapy for PTSD in high and low treatment responders.

Maples-Keller JL, Rauch SAM, Jovanovic T, Yasinski CW, Goodnight JM, Sherrill A, Black K, Michopoulos V, Dunlop BW, Rothbaum BO, Norrholm SD.J Anxiety Disord. 2019 Dec;68:102147. doi: 10.1016/j.janxdis.2019.102147. Epub 2019 Sep 21.PMID: 31669786

The clinical applications and practical relevance of human conditioning paradigms for posttraumatic stress disorder.

Zuj DV, Norrholm SD.Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:339-351. doi: 10.1016/j.pnpbp.2018.08.014. Epub 2018 Aug 19.PMID: 30134147

Fear Processing, Psychophysiology, and PTSD.

Norrholm SD, Jovanovic T.Harv Rev Psychiatry. 2018 May/Jun;26(3):129-141. doi: 10.1097/HRP.0000000000000189.PMID: 29734227

Extending prolonged exposure for veterans with posttraumatic stress disorder: When is enough really enough?

Ready DJ, Lamp K, Rauch SAM, Astin MC, Norrholm SD.Psychol Serv. 2020 May;17(2):199-206. doi: 10.1037/ser0000309. Epub 2018 Oct 18.PMID: 30335416