Bio
Seth D. Norrholm, PhD, is a translational neuroscientist with over 2 decades of research experience in furthering the understanding of the neurobiological mechanisms underlying fear-, anxiety-, trauma-, and stressor-related disorders and the psychiatric conditions with which these disorders are co-morbid. Dr. Norrholm has trained in both the “classical” bench-based neurosciences as well as within clinical arenas dedicated to the treatment of mood and anxiety disorders. Together with a network of collaborators, Dr. Norrholm has employed objective, psychophysiological methods to study the underpinnings of mammalian fear processing as well as the mechanisms mediating effective treatments for fear and anxiety. Dr. Norrholm has spent 20 years working within VA and DoD to develop effective treatment strategies for mood and anxiety disorders with interventions spanning pharmaceutical, surgical, behavioral, and alternative domains. He is a recognized world leader in posttraumatic stress disorder (PTSD) and Fear and recently joined our faculty as a Distinguished Visiting Professor in 2022.
When not working, Dr. Norrholm enjoys spending time with his wife and kids and their menagerie of animals as well as cheering on his beloved Florida State Seminoles and Philadelphia Eagles.
Education
B.A. in Psychology (1995) – University of Maryland at College Park, College Park, Maryland
M.A. in Neuroscience (1998) – University of Hartford/University of Connecticut Health Center, Hartford/Farmington, Connecticut
Ph.D. in Neuroscience (2001) – Florida State University, Tallahassee, Florida
Postdoctoral Fellow (2001-2003), College of Pharmacy, University of Kentucky
Postdoctoral Fellow (2003-2004), Department of Anatomy, University of South Florida
Postdoctoral Fellow (2004-2007), Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine
Ph.D. Respecialization in Clinical Psychology (2014-2019) – Emory University, Atlanta, Georgia
Professional Experience
2007 – 2008: Associate in Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
2008 – 2018: Assistant Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
2018 – 2019: Associate Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia
2014 – 2019: Full-time Faculty Member, Graduate Program in Neuroscience, Emory University, Atlanta, Georgia
2009 – 2019: Program Analyst/Principal Investigator, Atlanta VA Health Care System, Decatur, Georgia.
2019 – present: Associate Professor, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan
2019 – present: Scientific Director, Neuroscience Center for Anxiety, Stress, and Trauma (NeuroCAST), Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan
Honors & Awards
Recognized World Expert, Posttraumatic Stress Disorder, Expertscape, (2019)
Recognized World Expert, Fear, Expertscape, (2019)
Distinction in Scholarship Certificate, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology (2018)
Emory School of Medicine Researcher Appreciation Day Recognition (2018)
Military Medicine Article of the Year Award (2017)
National Institutes of Health, National Advisory Mental Health Council Workgroup on Tasks and Measures for Research Domain Criteria (RDoC), Recommended Paradigm, Acute Fear Construct, https://www.nimh.nih.gov/about/advisory-boards-and-groups/namhc/reports/behavioral-assessment-methods-for-rdoc-constructs#section-ii-a (2016)
Distinguished Scientific Contribution, Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences (2015)
Research and Scholarly Interests
Assessing the acquisition and extinction of learned fear using psychophysiological techniques (e.g., fear-potentiated startle, skin conductance, heart rate variability, and eye-tracking)
Clinical Psychopharmacology
Integrating objective measures of fear and anxiety during the implementation of cognitive behavioral therapies for mood and anxiety disorders
Virtual reality solutions for assessing the degree of and pathophysiological expression of fear
Imaginal and VR-based Prolonged Exposure Therapy
Learning and Memory
Publications
Maples-Keller J, Watkins LE, Nylocks KM, Yasinski C, Coghlan C, Black K, Jovanovic T, Rauch SAM, Rothbaum BO, Norrholm SD.Behav Res Ther. 2022 Jul;154:104124. doi: 10.1016/j.brat.2022.104124. Epub 2022 May 20.PMID: 35642990
Does COVID-19 count?: Defining Criterion A trauma for diagnosing PTSD during a global crisis.
Norrholm SD, Zalta A, Zoellner L, Powers A, Tull MT, Reist C, Schnurr PP, Weathers F, Friedman MJ.Depress Anxiety. 2021 Sep;38(9):882-885. doi: 10.1002/da.23209.PMID: 34469042
Reist C, Jovanovic T, Kantarovich D, Weingast L, Hollifield M, Novin M, Khalaghizadeh S, Jafari B, George R, Riser M, Woodford J, Norrholm SD.Behav Brain Res. 2021 Apr 23;404:113172. doi: 10.1016/j.bbr.2021.113172. Epub 2021 Feb 9.PMID: 33577879
Maples-Keller JL, Rauch SAM, Jovanovic T, Yasinski CW, Goodnight JM, Sherrill A, Black K, Michopoulos V, Dunlop BW, Rothbaum BO, Norrholm SD.J Anxiety Disord. 2019 Dec;68:102147. doi: 10.1016/j.janxdis.2019.102147. Epub 2019 Sep 21.PMID: 31669786
Zuj DV, Norrholm SD.Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:339-351. doi: 10.1016/j.pnpbp.2018.08.014. Epub 2018 Aug 19.PMID: 30134147
Fear Processing, Psychophysiology, and PTSD.
Norrholm SD, Jovanovic T.Harv Rev Psychiatry. 2018 May/Jun;26(3):129-141. doi: 10.1097/HRP.0000000000000189.PMID: 29734227
Ready DJ, Lamp K, Rauch SAM, Astin MC, Norrholm SD.Psychol Serv. 2020 May;17(2):199-206. doi: 10.1037/ser0000309. Epub 2018 Oct 18.PMID: 30335416