Bio
Dr. Kelley comes to USAFA from the University of Texas at San Antonio (UTSA). At UTSA, she received her PhD in analytical chemistry with a focus on mass spectrometric techniques under the mentorship of Dr. Stephan Bach. She then completed a post-doctoral fellowship in the lab of Dr. George Perry where she developed mass spectrometry methods (imaging and other) to elucidate the previously unrealized complexity of senile plaques in Alzheimer’s disease brain samples. Concurrently, she began her teaching career, course directing undergraduate analytical chemistry.
At USAFA, Dr. Kelley is the course director for analytical chemistry and is continuing research in mass spectrometry tissue imaging.
Education
Doctor of Philosophy, Chemistry, University of Texas at San Antonio, TX. (2017)
Bachelor of Science, Chemistry with Highest Honors, University of Texas at San Antonio, TX. (2013)
Professional Experience
Assistant Professor of Chemistry, U.S. Air Force Academy, CO. (2020 to present)
Post-Doctoral Fellow, University of Texas at San Antonio, TX. (2018-2020)
Lecturer, University of Texas at San Antonio, TX. (2018-2019)
Honors & Awards
“Alzheimer’s May Be More Complicated.”
KLRN SCITECH NOW, Season 3, Episode 8. April 5, 2018. TV Broadcast
“UTSA Researchers Gain Alzheimer’s Insights.”
Texas Standard Radio, April 3, 2018. Radio Broadcast
“UTSA Chemists Succeed in Developing Molecular View of Alzheimer’s.”
Rivard Report, March 30, 2018. Print News Article
Judith A. Walmsley Endowed Graduate Fund (Annual award for outstanding graduate work), University of Texas at San Antonio (2017)
UTSA Dept. of Chemistry GRA Research Award (Annual award for outstanding graduate work, University of Texas at San Antonio (2016)
Research and Scholarly Interests
Mass spectrometry imaging (MSI) method development, application of MSI and mass spectrometry-based analysis to neurodegenerative diseases (primarily Alzheimer’s disease) and forensics
Publications
Samenuk, G. M., Kelley, A. R., Perry, G., Bach, S.B.H. (2019) Rapid Method Towards Proteomic Analysis of Dried Blood Spots by MALDI Mass Spectrometry. Clinical Mass Spectrometry. 12, 30-6. DOI: Available Here.
*Kelley, A. R., Bach, S. B. H., and Perry, G. (2019) Analysis of Post-Translational Modifications in Alzheimer’s Disease by Mass Spectrometry. Biochem. Biophys. Acta. – Molecular Basis of Disease. 1865, 2040-47. DOI: Available Here.
*Kelley, A. R., Perry, G., and Bach, S. B. H. (2018) Characterization of Proteins Present in Isolated Senile Plaques from Alzheimer’s Diseased Brains by MALDI-TOF MS with MS/MS. ACS Chem Neuosci. 9, 708-14. DOI: Available Here.
*Kelley, A. R., Colley, M. E., Perry, G., and Bach, S. B. H. (2017) Incubation with Cu(II) and Zn(II) Salts Enhances MALDI-TOF Mass Spectra of Amyloid-beta and α-Synuclein Toward in-vivo Analysis. J. Mass Spectrom. 53, 162-71. DOI: Available Here.
*Kelley, A. R., Perry, G., Castellani, R. J., and Bach, S. B. H. (2016) Molecular Mapping Alzheimer’s Disease: MALDI Imaging of Formalin-Fixed, Paraffin-Embedded Human Hippocampal Tissue. Open Neurol J. 10, 88-98. DOI: Available Here.
*Kelley, A. R., Perry, G., Castellani, R. J., and Bach, S. B. H. (2015) Laser-Induced in-Source Decay Applied to the Determination of Amyloid-Beta in Alzheimer’s Brains. ACS Chem Neurosci. 7 (3), 261-8. DOI: Available Here.