United States Air Force Academy

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Dr. David Hale

Associate Professor of Biology

Department of Biology

Contact Information

(719) 333-6053

Email

Education

Ph.D., Zoology, Texas A&M University (1988)

Bachelor of Science, Zoology, Texas A&M University (1982)

Professional Experience

Graduate Faculty, Department of Biology, University of Colorado-Colorado Springs (2006-present)

Associate Professor, Department of Biology, U.S. Air Force Academy (2001-present)

Assistant Professor, Department of Biology, U.S. Air Force Academy (1998-2001)

Lecturer/Senior Lecturer, Department of Biology, Texas A&M University (1994-1998)

Postdoctoral Fellow, Department of Biology, Yale University, Connecticut (1991-1994)

Postdoctoral Fellow, The Jackson Laboratory (1989-1991)

Postdoctoral Associate, The Jackson Laboratory, Maine (1988-1989)

Research Assistant, Department of Biology, Texas A&M University (1984-1988)

Teaching Assistant, Department of Biology, Texas A&M University, Texas (1983-1986)

Laboratory Technician, Veterinary Toxicology and Entomology Laboratory, USDA, Texas (1982-1983)

Animal Technician, Southwest Foundation for Biomedical Research, Texas (1980-1981)

Honors & Awards

Master Teacher Award, Department of Biology, U.S. Air Force Academy (2009)

Captain William F. Goodner Award for Teaching Excellence, Department of Biology, U.S. Air Force Academy (2002)

Promethean Award for Educational Leadership, Department of Biology, U.S. Air Force Academy (2000-2001)

Professor of the Year Award, Alpha Phi Foundation (Texas A&M University Chapter) (1997-1998)

Postdoctoral Research Fellowship in Environmental Biology, National Science Foundation (1992-1994)

Burroughs Wellcome Fund Postdoctoral Fellowship, Life Sciences Research Foundation (1989-1992)

Distinguished Graduate Student Research Award, Graduate College and Association of Former Students, Texas A&M University (1988)

Biology Graduate Student Achievement Award, Biology Graduate Student Association and Department of Biology, Texas A&M University (1987)

Academic Excellence Award Scholarship, Texas A&M University (1985-1986)

Cum Laude Honors Graduate, College of Science, Texas A&M University (1982)

Phi Eta Sigma, Texas A&M University, (1979)

Research and Scholarly Interests

Mammalian Field and Biodiversity Studies

Vertebrate Cytogenetics and Genome Evolution

Evolution and Homology of Vertebrate Sex Chromosomes

Genetics of Male-Hybrid Sterility in Mammals

Comparative Genome Mapping in Mammals

Publications

Greenbaum IF, Hale DW, Fuxa KP (1986) The mechanism of autosomal synapsis and the substaging of zygonema and pachynema from deer mouse spermatocytes. Chromosoma 93:203-212.

Greenbaum IF, Hale DW, Fuxa KP (1986) Synaptic adaptation in deer mice: A cellular mechanism for karyotypic orthoselection. Evolution 40:208-213.

Hale DW (1986) Heterosynapsis and suppression of chiasmata within heterozygous pericentric inversions of the Sitka deer mouse. Chromosoma 94:425-432.

Hale DW, Greenbaum IF (1986) Spontaneous occurrence of XYY primary spermatocytes in the Sitka deer mouse. Journal of Heredity 77:131-132.

Hale DW, Greenbaum IF (1986) The behavior and morphology of the X and Y chromosomes during prophase I in the Sitka deer mouse (Peromyscus sitkensis). Chromosoma 94:235-242.

Hale DW, Greenbaum IF (1988) Chromosomal pairing in deer mice heterozygous for the presence of heterochromatic short arms. Genome 30:44-47.

Hale DW, Greenbaum IF (1988) Synapsis of a chromosomal pair heterozygous for a pericentric inversion and the presence of a heterochromatic short arm. Cytogenetics and Cell Genetics 48:55-57.

Hale DW, Ryder EJ, Sudman PD, Greenbaum IF (1988) Application of synaptonemal complex techniques for determination of diploid number and chromosomal morphology in birds. Auk 105:776-779.

Hale DW, Sudman PD, Greenbaum IF (1988) Heterosynapsis and suppression of chiasmata within heterozygous pericentric inversions of deer mice. Genome 30 (Suppl. 1):131.

Sudman PD, Hale DW, Greenbaum IF (1988) Chromosome pairing and crossing over in Peromyscus polymorphic for the amount and distribution of heterochromatin. Genome 30 (Suppl. 1):131.

Hale DW (1989) A reevaluation of chromosomal variation in populations of Peromyscus maniculatus along an elevational gradient. Evolution 43:226-228.

Hale DW, Hanks BG, Bickham JW, Greenbaum IF (1989) Centriolar length variability in testicular cells from side-necked turtles. Journal of Submicroscopic Cytology and Pathology 21:211-214.

Sudman PD, Greenbaum IF, Hale DW, Smith SA (1989) Synaptic adjustment in Peromyscus beatae (Rodentia: Cricetidae) heterozygous for interstitial heterochromatin. Cytogenetics and Cell Genetics 50:1-5.

Greenbaum IF, Hale DW, Sudman PD, Nevo E (1990) Synaptonemal complex analysis of mole rats (Spalax ehrenbergi): unusual polymorphisms of chromosome 1. Genome 33:898-902.

Greenbaum IF, Hale DW, Sudman PD, Nevo E (1991) Synaptonemal complex analysis of mole rats (Spalax ehrenbergi): unusual polymorphisms of chromosome 1. Cytogenetics and Cell Genetics 56:223.

Derr JN, Hale DW, Ellsworth DL, Bickham JW (1991) Fertility in an F1 male hybrid of white-tailed deer (Odocoileus virginianus) X mule deer (O. hemionus). Journal of Reproduction and Fertility 93:111-117.

Eicher EM, Hale DW, Hunt PA, Lee BK, Tucker PK, King TR, Eppig JT, Washburn LL (1991) The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region. Cytogenetics and Cell Genetics 57:221-230.

Hale DW, Hedin MC, Smith SA, Sudman PD, Greenbaum IF (1991) The effect of heterochromatin on synapsis of the sex chromosomes of Peromyscus (Rodentia, Cricetidae). Cytogenetics and Cell Genetics 56:48-56.

Hale DW, Hunt PA, Tucker PK, Eicher EM (1991) Synapsis and obligate recombination between the sex chromosomes of male laboratory mice carrying the Y* rearrangement. Cytogenetics and Cell Genetics 57:231-239.

Eicher EM, Lee BK, Washburn LL, Hale DW, King TK (1992) Telomere-related markers for the pseudoautosomal region of the mouse genome. Proceedings of the National Academy of Sciences, USA 89:2160-2164.

Hale DW (1992) Sex chromosomes, heterochromatin, and retrotransposon accumulation in deer mice. Evolution 46:1955-1958.

Bickham JW, Hanks BG, Hale DW, Martin JE (1993) Ploidy diversity and the production of balanced gametes in male twist-necked turtles (Platemys platycephala). Copeia 1993:723-727.

Hale DW, Washburn LL, Eicher EM (1993) Meiotic abnormalities in hybrid mice of the C57BL/6J X Mus spretus cross suggest a cytogenetic basis for Haldane's rule of hybrid sterility. Cytogenetics and Cell Genetics 63:221-234.

Smith LR, Stavinoha CA, Hale DW, Greenbaum IF (1993) Chromosomal homology and evolutionary relationships of Peromyscus sejugis and P. slevini. Cytogenetics and Cell Genetics 63:253.

Greenbaum IF, Gunn SJ, Smith SA, McAllister BF, Hale DW, Baker RJ, Engstrom MD, Hamilton MJ, Modi WS, Robbins LW, Rogers DS, Ward OG, Dawson WD, Elder FFB, Lee MR, Pathak S, Stangl FB (1994) Cytogenetic nomenclature of deer mice, Peromyscus (Rodentia): revision and review of the standardized karyotype. Report of the Committee for the Standardization of Chromosomes of Peromyscus. Cytogenetics and Cell Genetics 66:181-195.

Hale DW (1994) Is X-Y recombination necessary for spermatocyte survival during mammalian spermatogenesis? Cytogenetics and Cell Genetics 65:278-282.

Berend SA, Hale DW, Engstrom MD, Greenbaum IF (1995) Cytogenetic analysis of the neo-XY sex-chromosomal system of collared lemmings. Cytogenetics and Cell Genetics 69:120.

Berend SA, Hale DW, Engstrom MD, Greenbaum IF (1995) Cytogenetic analysis of B-chromosomal pairing in collared lemmings. Cytogenetics and Cell Genetics 71:399.

Hale DW (1995) Premeiotic nondisjunction as a source of aneuploid meiocytes, gametes, and offspring. Cytogenetics and Cell Genetics 69:121.

Hale DW (1995) Obligate recombination between the X and Y chromosomes of mammals. Cytogenetics and Cell Genetics 71:399.

Houseal TW, Cook JA, Modi WS, Hale DW (1995) Identification of highly conserved loci by genome painting. Chromosome Research 3:175-181.

Berend SA, Hale DW, Engstrom MD, Greenbaum IF (1996) Meiotic analysis of chromosomal rearrangements and their potential role in reproductive isolation in collared lemmings. Cytogenetics and Cell Genetics 74:307.

Hale DW (1996) Mammalian Spermatogenesis. In: Verma RS (ed) Advances in Genome Biology 4: Genetics of Sex Determination (JAI Press, Inc., Greenwich CT), pp. 249-304.

Myers S, Hale DW, Greenbaum IF (1996) Karyotypic variation in deer mice (Peromyscus maniculatus) from the northeast. Cytogenetics and Cell Genetics 74:306.

Berend SA, Hale DW, Engstrom MD, Greenbaum IF (1997) Cytogenetics of collared lemmings (Dicrostonyx groenlandicus). I. Meiotic analyses and evolution of the neo-XY sex-chromosome system. Cytogenetics and Cell Genetics 79:288-292.

Meyers Unice SM, Hale DW, Greenbaum IF (1998) Karyotypic variation in populations of deer mice (Peromyscus maniculatus) from eastern Canada and the northeastern United States. Canadian Journal of Zoology 76:584-588.

Unangst ET, Hale DW, Granger M, Blair M (1999) Peromyscus maniculatus body composition model. Peromyscus Newsletter 28:19.

vanTuinen P, Mootnick AR, Kingswood SC, Hale DW, Kumamoto AT (1999) Complex, compound inversion/translocation polymorphism in an ape: presumptive intermediate stage in the karyotypic evolution of the agile gibbon Hylobates agilis. American Journal of Physical Anthropology 110:129-142.

Hale DW, Unangst ET, Hall ZG, Hendrickson JD, Schichtle DR, Schongalla MS (2000) Use of chromosomal markers for distinguishing Peromyscus maniculatus and P. leucopus on the U.S. Air Force Academy reservation. Peromyscus Newsletter 30:14.

Hale DW, Washburn LL, Eicher EM (2000) Meiotic behavior of the sex chromosomes in XY female and hermaphroditic mice of the C57BL/6J-YPOS strain. Cytogenetics and Cell Genetics 90:160.

Smith LR, Hale DW, Greenbaum IF (2000) Systematic implications of chromosomal data from two insular species of Peromyscus from the Gulf of California. Journal of Heredity 91:162-165.

Unangst ET, Hale DW, Granger M, Blair M (2000) Estimating body composition for live Peromyscus maniculatus. Peromyscus Newsletter 29:17-18.

*Berend SA, *Hale DW, Engstrom MD, Greenbaum IF (2001) Cytogenetics of collared lemmings (Dicrostonyx groenlandicus). II. Meiotic behavior of B chromosomes suggests a Y-chromosome origin of supernumerary chromosomes. Cytogenetics and Cell Genetics 95:85-91. [*authors contributed equally to completion of project and paper]

Hall ZG, Hendrickson JD, Unangst ET, Hale DW (2001) Use of chromosomal markers for distinguishing common deer mice and white-footed mice on the U.S. Air Force Academy reservation. Journal of the Colorado-Wyoming Academy of Science 23:14.

Unangst ET, Blair MJ, Granger MW, Hale DW (2001) Lab fattening and non-invasive estimates of body composition in deer mice. Prairie Naturalist 33:183-193.

Hale DW, Washburn LL, Eicher EM (2002) Cytogenetics of unusual sex-chromosomal phenotypes generated from the Y* mutation in laboratory mice. Cytogenetic and Genome Research 97:265-266.

Hale DW, Wiechert KP (2007) Hantavirus pulmonary syndrome case at the U.S. Air Force Academy. Peromyscus Newsletter 42:32-35.

Hale DW (2008) Apparent absence of deer mice at various localities in the Labrador region of eastern Canada. Peromyscus Newsletter 43:21-25.

Sikes RS, Gannon WL, and The Animal Care and Use Committee of the American Society of Mammalogists (2011) Guidelines for the use of wild mammals in research by the American Society of Mammalogists. Journal of Mammalogy 92:235-253.

Noble CW, Bono JM, Pigage HK, Hale DW, Pigage JC (2016) Fine-scale genetic structure in female mule deer (Odocoileus hemionus). Western North American Naturalist 76:417-426.

Sikes RS, and The Animal Care and Use Committee of the American Society of Mammalogists (2016) 2016 Guidelines of the American Society of Mammalogists for the use of wild mammals in research and education. Journal of Mammalogy 97:663-688.